Hide in Plain Sight
Monday, June 16th, 2008
BBC Medical Science — Normally the immune system works out the difference between friend and
foe by looking for “foreign” surface proteins and, by cutting them
loose, the amoeba is able to stay undisturbed. …
The tiny creature behind tens of thousands of dysentery deaths each
year has a crafty method of slipping past our immune system, claim
researchers.
US scientists say amoebae can get rid of giveaway chemicals on their surface. The study in the journal Genes and Development suggests a similar technique helps malaria parasites get into human cells. …
It is suspected that the number of people infected by amoebae amounts to millions worldwide.
Most of them will never suffer bloody diarrhoea, which is the first
sign of amoebic dysentery, an infection which kills approximately
70,000 people each year.
In most symptomless cases, the body’s immune system eventually gets rid of the infection, but it can persist for years on end.
Researchers from Johns Hopkins and Stanford universities in the
US believe they have found out why the single-celled organism is
capable of evading the immune system for so long.
Existing research on the plasmodium malaria parasite revealed
that it used a type of cell chemical called a “rhomboid enzyme” to help
it get into the host cell.
A scan of the DNA of other parasites revealed the same chemical
in amoebae, and led to the discovery this chemical was capable of
getting rid of a protein called lectin found on its surface. (06/16/08)
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